Supporting the Search for Novel Vaccines
Vaccines represent one of the most crucial public health advances in human history. However, the discovery, development, and manufacturing of prophylactic and therapeutic vaccines to protect people against infectious and other diseases remains very challenging.
This is where Genedata comes in.
Genedata helped us get to the next level of streamlining our data management workflow
Ciaran Scallan, Ph.D.
Vice President, Vaccine Technology & Molecular Biology
Given their track-record of success, Genedata’s platform was the clear choice to support and integrate our full cell therapy discovery and development efforts.
Marc Van Dijk, Ph.D.
Chief Technology Officer
We work at a fast pace and push the boundaries of science. Genedata provided a platform that could be rolled out with minimal customization required
Ciaran Scallan, Ph.D
Vice President, Vaccine Technology & Molecular Biology
Increase Research Efficiency
- Manages the entire research and development workflow for protein-based vaccines as well as novel vaccine technologies such as viral vector- and mRNA-based vaccines
- Registers, produces, and characterizes recombinant nucleic acids, proteins, and viruses
- Investigates novel antigens and identifies relevant epitopes using practical visualizations and analytical tools
- Analyzes data across projects and optimizes processes by systematically identifying R&D process bottlenecks
Set Up HT Development Processes
- Automates and scales up cloning, screening, engineering, expression, and purification of vaccine candidates and their components
- Enables well-organized bioprocess development (USP, DSP, formulation, and analytics) for all vaccine types including support for synthetic and cell-free processes
- Integrates all lab instruments and robotic devices via open architecture to automate data transfer, e.g., during formulation screening
- Facilitates automated communication and transparent handover of materials and data between different teams and functions
Monitor Vaccine Quality & Integrity
- Integrates all characterization and analytics data (e.g., antigens, protein subunits, viruses, nucleic acids)
- Identifies potential developability risks based on integrated product quality assessment
- Correlates manufacturing process parameters with product quality; full QbD support
- Generates full historical record for each vaccine candidate in a single mouse click
Ensure Traceability & Compliance
- Enables full traceability from raw materials to final products including all aliquots and analytical samples
- Establishes a single source of truth by centralizing data management and providing real-time access to all project information
- Relies on an established enterprise platform based on industry-standard architecture
Digitalizing Next-Gen Vaccine R&D with Genedata
- Supports innovative DNA and RNA vaccine engineering (e.g., self-amplifying RNA)
- Enables novel adjuvants discovery (e.g., via high throughput screening of immuno-potentiators)
- Facilitates development of promising new vaccine presentation and delivery technologies (polysaccharide vaccines, GMMA, alpha-virus vectors, etc.)
- Performs reverse vaccinology based on whole-genome analysis of the pathogen using available computational tools
- Empowers discovery of promising cancer vaccines
Supporting Our Customers to Advance Vaccine R&D
Characterizing SARS-CoV-2 Candidate Vaccine Antigens
Learn how reasearchers from Sanofi used Genedata solutions for accelerated MS-based in-depth characterization of candidate vaccine antigens for SARS-CoV-2.
Paving the Way for SARS-CoV-2 mRNA Vaccines
Learn about the major themes and advancements in the field of cell and gene therapy presented at ASGCT 2021.
Towards Novel RNA and Viral Vector Modalities
See details of a workflow support platform that enables the digitalization of vaccine research and development to facilitate communication, minimize resource-intensive errors, and accelerate the vaccine R&D processes.
Faster, Safer, Viral Detection in Biologics Manufacturing
Read how Genedata supports manufacturers to reduce both time and risk by incorporating NGS-based testing into their workflows.