Advancing Bispecific Antibody Discovery
Genedata Biologics® enables the systematic design, cloning, and testing of large numbers of bi- and multi-specifics, such as knobs-into-holes (KinH), Fab-scFv, IgG-scFv, DuoBody, DVD-Ig, tandem-scFv-Fc and their parametric variants (e.g., linkers, V-domain order, Fc).
Bispecific Antibody Engineering
Genedata Biologics automates downstream expression, purification, and characterization processes, which substantially increases throughput. By identifying the most successful combination of antigen binders and formats, the platform resolves major bottlenecks in high-throughput molecular biology and cloning processes and directly integrates with laboratory automation equipment to scale up cloning and production. With the automatic aggregation of all assay and analytics results, the platform also enables multi-parameter lead selection.
Genedata Biologics was the clear choice as a backbone system to support the full diversity of our complex and rapidly evolving antibody discovery processes in the US and the UK.
We determined that Genedata Biologics was the best solution to fully address all our unique workflow requirements as it enables scale up of the screening, engineering, production and testing of complex multi-specific antibody candidates.
Genedata Biologics provides a flexible architecture and includes built-in biopharma domain knowledge, which can handle our proprietary bispecific antibody discovery processes.
Genedata Biologics is a perfect fit for our approach, because it comes with built-in functionalities that support the specialized immuno-oncology applications we require ... to handle our bispecific engineering and TCR discovery and optimization workflows without any customization.
Customer Stories
MorphoSys Digitalizes Large-Molecule R&D
Two-minute video highlighting how Genedata's bulit-for-biologics platform is accelerating R&D at MorphoSys.
Accelerating Development of TCRs and Bispecifics
“Genedata Biologics is a perfect fit for our approach, because… we anticipate that the platform will be able to handle our bispecific engineering and TCR discovery and optimization workflows without any customization.”
Building on Genedata for Cell Therapy Innovation
"The implementation of the Genedata platform has helped us to digitalize Immatics’ TCR-related R&D. This means that time-consuming paperwork is minimized, and we can easily find information when it is needed."
Streamlining Cancer Immunotherapy R&D
"To increase the throughput of our bispecific discovery program we needed a flexible E2E workflow system. We determined that Genedata Biologics was the best solution to fully address all our unique workflow requirements."