Genedata Biologics® enables an efficient and flexible optimization and engineering of both antibodies and proteins, including novel molecule formats such as bispecific antibodies, fusion proteins, and Fc-engineered molecules. The system supports a variety of engineering strategies, including affinity maturation (e.g., by PCR), germlining, humanization, murinization, antibody reformatting (e.g., scFv to Fab to IgG), isotype switching, and directed engineering (e.g., removal of glycosylation sites). Genedata Biologics stores all engineered biomolecules and their underlying molecular ancestry.
Tools for automatic in silico construction, registration, and annotation of engineered molecule sequences and relevant plasmid maps make manual sequence handling unnecessary. Genedata Biologics provides a central and structured registry for all vectors encoding the engineered protein variants. Integrated tools analyze sequence and assay data to systematically assess engineered molecule variants, enabling the identification of residues that are critical for achieving the desired properties of the engineered molecules.