Identification of a Class of WNK Isoform-Specific Inhibitors Through High-Throughput Screening

Drug Design, Development and Therapy
January 20, 2023

WNK [with no lysine (K)] kinases are serine/threonine kinases associated with familial hyperkalemic hypertension (FHHt). WNKs are therapeutic targets for blood pressure regulation, stroke and several cancers including triple negative breast cancer and glioblastoma. Here, we searched for and characterized novel WNK kinase inhibitors.

Genedata Screener was used to analyze the high-throughput screening data.