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Automating LC-UV-MS-Based Analytics in Therapeutic Oligonucleotide Process Development

In this Case Study, scientists at F. Hoffmann-La Roche describe how they worked together with Genedata to design and implement a streamlined data processing workflow for UV-LC-MS-based analysis of the large number of samples generated during optimization of oligonucleotide drug synthesis. The end-to-end solution enabled them to keep pace with throughput demands while increasing the quality of support that they deliver to their colleagues working in process chemistry. In addition, the highly automated solution minimized user intervention and freed scientists from performing tedious routine work, enabling MS experts to focus on challenges that require their specialist knowledge.