情報計算化学生物学会（CBI学会）2023年大会
Tokyo, Japan
October 23–26, 2023
2023年10月23日（月）～26日（木）タワーホール船堀で開催されるCBI学会2023年大会にてポスター発表を実施いたします。
Genedata Screener®は、アッセイ解析の自動化、生データとアッセイ結果の品質バリデーション、そして組織内外に分散するあらゆるアッセイ情報の統合を実現します。複雑な実験データを統合することで、プロジェクトにおける意思決定を強化し、より予測的かつAI駆動型の創薬基盤の構築を促します。
Genedataに関する日本語の情報をご希望の方は、japan(at)genedata.comへお気軽にお問い合わせください。
ポスター発表
【P09-07】A New Workflow Automating Data Analysis in Gene Expression Screens Across Assay Formats Produces Consistent Results at Scale and Efficiency（Evotec社、遺伝子発現スクリーニングにおけるデータ解析の自動化）
Genedata Screener® Scientific Account Manager 川合 茉利奈
Developing RNA-targeted drugs holds the promise for a dramatic increase in therapeutically addressable biological processes that are far beyond the reach of protein-targeted drugs, such as pre-mRNA splicing or modulation of gene expression by noncoding RNAs. Quantitative reverse transcription PCR (RT-qPCR) is a recent, scalable technique for small molecule screening, allowing determination of up- or down-regulation of gene expression induced by a molecule under test. Evotec has developed accelerated experimental and data analysis workflows that allow RT-qPCR assays to be run at the scale of HTS. In conjunction with the process automation, we present here a highly scalable and highly automated data analysis workflow. We show how it can be used for the rapid characterization of large sets of molecules by induced expression changes, identification of cytotoxic compounds, and in-vitro estimation of therapeutic windows from shifts in concentration-response curves. This workflow has been implemented in Genedata Screener. It enables Evotec to streamline data processing from such experiments by a seamless integration with standard HTS data analysis processes - starting from compound logistics to one-click reporting of final results, significantly contributing to shortened cycle time. We will discuss the advantages and scientific novelties of our system at the poster presentation.
