CRISPR Therapies
Do you want to deliver CRISPR therapies to patients faster by improving screening, enhancing automation, and using NGS for biosafety testing? Do you need to track the entire process from discovery through to and beyond clinical trials in a secure and compliant way?
This is where Genedata comes in.
Our Customers
- CRISPR Discovery. Automated.
- Genome Editing. Precise.
- Data Management. Refined.
- Quality Control. Validated.
- Compliance Excellence. Ensured.
- Innovative Therapies. Delivered.
CRISPR Discovery. Automated.
- Bring workflows in house, automate routine tasks, and standardize sample handling in the discovery and screening of novel CRISPR therapeutics.
- Track experimental process from design and sample preparation to analysis, visualization, and sharing of results.
- Automate workflows with wizard-based Playbooks that support comprehensive analysis and reporting and make NGS analysis accessible to non-bioinformaticians.
Genome Editing. Precise.
- Predict and visualize novel gRNAs and off-target edits across the genome in a few clicks.
- Generate specific PCR primers to test predicted gRNAs with precise position, sequence, and specificity.
- Import and integrate in-house and publicly available genomic and phenotypic data to efficiently validate genome editing experiments.
Data Management. Refined.
- Overcome complex data management bottlenecks with a central single source of truth.
- Customize and lock down data management processes to eliminate errors caused by manual data handling.
- Protect institutional memory across multiple locations while complying with strict regulatory and security requirements.
- Capture and navigate full CRISPR-projects as well as batch history and lineages for edited cells.
Quality Control. Validated.
- Ensure that routine biosafety testing is reproducible and accurate, enabling detection of adventitious agents that could contaminate starting material and final samples.
- Set up pre-configured custom go/no-go signal rules to automatically flag and disqualify samples that do not meet the required stability, purity, and potency standards.
Compliance Excellence. Ensured.
- Ensure all data comply with FAIR principles.
- Access, monitor, and track results across the entire R&D chain through data democratization and collaboration.
- Validate in-house workflows for use in GxP environments, enabling transparent reporting and 21 CFR Part11-compliant documentation.
- Benefit from validation support services for Computerized System Validation (CSV) projects.
Innovative Therapies. Delivered.
- Make multi-source R&D data easily accessible from a single access point.
- Easily integrate multi-modal R&D data with data from previous clinical trials, real-world data, and publicly available datasets to improve understanding of disease pathways, assess efficacy of therapies, and understand patient profiles.
- Identify biomarkers to include the right clinical trial patients to demonstrate therapeutic benefit and improve the chance of success.
- Streamline submissions to regulatory authorities by performing analyses in a GxP-validated environment.
Selected Use Cases
Precise Genome Editing for CRISPR Data Management and Analysis
Genedata Selector simplifies complex CRISPR experiments and NGS data management, providing a secure platform to predict gRNAs, generate PCR primers, and integrate genomic data for efficient genome editing validation.
CRISPR Screening for Enhanced mRNA Delivery via Nanoparticles
Arrayed CRISPR screening identifies novel pathways that enhance mRNA delivery via MC3 lipid nanoparticles, shedding light on cellular processes and improving therapeutic potential.
Automated High-Throughput Testing for Oligonucleotide Therapeutics
Fully automated workflow enables high-throughput identity testing of oligonucleotide therapeutics, ensuring stringent quality control and impurity identification for diverse nucleic acid-based biotherapeutics and vaccines.