Scientific Publications

The peer-reviewed publications listed below each acknowledge support from Genedata.

Title Application Year
Microbiome dynamics and adaptation of expression signatures during methane production failure and process recovery NGS 2017
Identification of multiple serine to asparagine sequence variation sites in an intended copy product of LUCENTIS® by mass spectrometry Mass Spectrometry 2017
Unbiased in-depth characterization of CEX fractions from a stressed monoclonal antibody by mass spectrometry Mass Spectrometry 2017
Xenobiotic metabolism in differentiated human bronchial epithelial cells NGS, Omics 2016
The exposome in practice: Design of the EXPOsOMICS project Toxicogenomics, NGS, Omics 2016
TMEM45A, SERPINB5 and p16INK4A transcript levels are predictive for development of high-grade cervical lesions NGS, Omics, Microarray 2016
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys Hit & Lead Identification 2016
Positive Allosteric Modulation of the Glucagon-like Peptide-1 Receptor by Diverse Electrophiles Hit & Lead Identification, HCS 2016
Identification of differential PI3K pathway target dependencies in T-cell acute lymphoblastic leukemia through a large cancer cell panel screen Compound Combinations 2016
Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors HTS 2016
Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate HCS, HTS 2016
A Generic Platform for Cellular Screening Against Ubiquitin Ligases HCS, HTS 2016
Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products HTS 2016
Preferential germline usage and VH/VL pairing observed in human antibodies selected by mRNA display Biologics 2015
Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective Microarray 2015
Caspase-8 activation by TRAIL monotherapy predicts responses to IAPi and TRAIL combination treatment in breast cancer cell lines Hit & Lead Identification 2015
Reduced gene expression levels after chronic exposure to high concentrations of air pollutants Toxicogenomics, NGS 2015
Unlocking the Potential of High-Throughput Drug Combination Assays Using Acoustic Dispensing HTS 2015
Combining AZD8931, a novel EGFR/HER2/HER3 signalling inhibitor, with AZD5363 limits AKT inhibitor induced feedback and enhances antitumour efficacy in HER2-amplified breast cancer models Hit & Lead Identification 2015
Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration HTS 2015
Identification of the Lipodepsipeptide MDN-0066, a Novel Inhibitor of VHL/HIF Pathway Produced by a New Pseudomonas Species HCS 2015
MS1-Based Label-Free Proteomics Using a Quadrupole Orbitrap Mass Spectrometer Mass Spectrometry 2015
Liquid chromatography high-resolution mass spectrometry for fatty acid profiling Mass Spectrometry 2015
New Ikarugamycin Derivatives with Antifungal and Antibacterial Properties from Streptomyces zhaozhouensis HCS 2014
diXa: a Data Infrastructure for Chemical Safety Assessment Toxicogenomics 2014
Identification of specific mRNA signatures as fingerprints for carcinogenesis in mice induced by genotoxic and non-genotoxic hepatocarcinogens Microarray, Statistical Analysis, Toxicogenomics 2014
A Novel In Vitro Approach for Simultaneous Evaluation of CYP3A4 Inhibition and Kinetic Aqueous Solubility HCS 2014
Interference of peritoneal dialysis fluids with cell cycle mechanisms Microarray, Statistical Analysis, Omics 2014
Optimizing a Ultrahigh pressure liquid chromatography-Time of Flight-Mass spectrometry approach using a novel sub-2 μm core shell particle for in depth lipidomic profiling of Caenorhabditis elegans Mass Spectrometry 2014
Gene expression identifies heterogeneity of metastatic behavior among high-grade non-translocation associated soft tissue sarcomas. Microarray 2014
Identification of tubular injury microRNA biomarkers in urine: comparison of next-generation sequencing and qPCR-based profiling platforms NGS 2014
DNA methylation markers for early detection of women's cancer: promise and challenges NGS 2014
Modeling the clinical phenotype of BTK inhibition in the mature murine immune system Microarray, Statistical Analysis 2014
Chemical allergen induced perturbations of the mouse lymph node DNA methylome NGS 2014
Testing chemical carcinogenicity by using a transcriptomics HepaRG-based model? Microarray, Statistical Analysis 2014
Functional characterization of a Penicillium chrysogenum mutanase gene induced upon co-cultivation with Bacillus subtilis Microarray 2014
Role of voltage gated Ca2+ channels in rat visceral hypersensitivity change induced by 2,4,6-trinitrobenzene sulfonic acid Microarray, Statistical Analysis 2014
Activation of the alternative sigma factor SigB of Staphylococcus aureus following internalization by epithelial cells - an in vivo proteomics perspective Mass Spectrometry 2014
Eribulin mesylate exerts specific gene expression changes in pericytes and shortens pericyte-driven capillary network in vitro Microarray 2014
Effect of environment and genotype on commercial maize hybrids using LC/MS-based metabolomics Mass Spectrometry 2014
Identifying Small Molecules which Inhibit Autophagy: a Phenotypic Screen Using Image-Based High-Content Cell Analysis Hit & Lead Identification, HTS, HCS 2014
Phenotype of htgA (mbiA), a recently evolved orphan gene of Escherichia coli and Shigella, completely overlapping in antisense to yaaW Mass Spectrometry 2014
Micronuclei in Cord Blood Lymphocytes and Associations with Biomarkers of Exposure to Carcinogens and Hormonally Active Factors, Gene Polymorphisms, and Gene Expression: The NewGeneris Cohort. NGS, Statistical Analysis, Omics 2013
Transcriptomic analysis of genetically defined autism candidate genes reveals common mechanisms of action Microarray 2013
Data visualization in environmental proteomics Mass Spectrometry 2013
Differential Host Response, Rather Than Early Viral Replication Efficiency, Correlates with Pathogenicity Caused by Influenza Viruses Microarray, Statistical Analysis 2013
Sphingosine Kinase Activity Is Not Required for Tumor HCS 2013
Increased extracellular matrix and proangiogenic factor transcription in endothelial cells after cocultivation with primary human osteoblasts NGS, Statistical Analysis 2013
Balibalosides, an Original Family of Glucosylated Sesterterpenes Produced by the Mediterranean Sponge Oscarella balibaloi HCS 2013
Feedstock and Biocatalyst Optimization Starts with an Integrated Genome Data Management Platform NGS, Omics, Strain Development 2013