Scientific Publications

The peer-reviewed publications listed below each acknowledge support from Genedata.

Title Application Year
EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex HTS 2020
Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors Compound Combinations 2019
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity Compound Combinations 2019
Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1 Biophysics 2019
A flexible high content imaging assay for profiling macrophage efferocytosis HCS 2019
SRSF1 and PTBP1 Are trans-Acting Factors That Suppress the Formation of a CD33 Splicing Isoform Linked to Alzheimer's Disease Risk Compound Combinations 2019
Discovery of retinoic acid receptor agonists as proliferators of cardiac progenitor cells through a phenotypic screening approach HCS 2019
Considerations for improved performance of competition association assays analysed with the Motulsky‐Mahan's “kinetics of competitive binding” model Mechanistic Analysis 2019
N-glycans of complex glycosylated biopharmaceuticals and their impact on protein clearance Mass Spectrometry 2019
DMSO induces drastic changes in human cellular processes and epigenetic landscape in vitro Mass Spectrometry, Toxicogenomics 2019
Acoustic Mist Ionization Platform for Direct and Contactless Ultrahigh-Throughput Mass Spectrometry Analysis of Liquid Samples HTS, Mass Spectrometry, Label-free 2019
Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways HTS 2019
Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides HTS 2019
Optimisation of Milk Protein Top-Down Sequencing Using In-Source Collision-Induced Dissociation in the Maxis Quadrupole Time-of-Flight Mass Spectrometer Mass Spectrometry 2018
The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis HCS, Imaging 2018
Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors Compound Combinations 2018
Considerations for Optimization of High-Throughput Sequencing Bioinformatics Pipelines for Virus Detection NGS 2018
PROMIS, global analysis of PROtein–metabolite interactions using size separation in Arabidopsis thaliana Mass Spectrometry 2018
Genetic and transcriptional evolution alters cancer cell line drug response HTS 2018
Know When You Don't Know: A Robust Deep Learning Approach in the Presence of Unknown Phenotypes HCS, Imaging 2018
In vitro and in silico analysis of the effects of D2 receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations Mechanistic Analysis 2018
High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl-2 Binding HTS 2018
Characterization and Validation of a Human 3D Cardiac Microtissue for the Assessment of Changes in Cardiac Pathology HCS 2018
Network analysis of coronary artery disease risk genes elucidates disease mechanisms and druggable targets. NGS 2018
Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors HTS 2018
Developing Deep Learning Applications for Life Science and Pharma Industry HCS, HTS, Imaging 2018
Integration of an In Situ MALDI-Based High-Throughput Screening Process: A Case Study with Receptor Tyrosine Kinase c-MET Mass Spectrometry, HTS, Label-free 2017
Methylation patterns in serum DNA for early identification of disseminated breast cancer NGS 2017
The potential of circulating tumor DNA methylation analysis for the early detection and management of ovarian cancer NGS 2017
Unified Software Solution for Efficient SPR Data Analysis in Drug Research Surface Plasmon Resonance, Biophysics 2017
Microbiome dynamics and adaptation of expression signatures during methane production failure and process recovery NGS 2017
Identification of multiple serine to asparagine sequence variation sites in an intended copy product of LUCENTIS® by mass spectrometry Mass Spectrometry 2017
Unbiased in-depth characterization of CEX fractions from a stressed monoclonal antibody by mass spectrometry Mass Spectrometry 2017
Xenobiotic metabolism in differentiated human bronchial epithelial cells NGS, Omics 2016
The exposome in practice: Design of the EXPOsOMICS project Toxicogenomics, NGS, Omics 2016
TMEM45A, SERPINB5 and p16INK4A transcript levels are predictive for development of high-grade cervical lesions NGS, Omics, Microarray 2016
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys Hit & Lead Identification 2016
Positive Allosteric Modulation of the Glucagon-like Peptide-1 Receptor by Diverse Electrophiles Hit & Lead Identification, HCS 2016
Identification of differential PI3K pathway target dependencies in T-cell acute lymphoblastic leukemia through a large cancer cell panel screen Compound Combinations 2016
Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors HTS 2016
Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate HCS, HTS 2016
A Generic Platform for Cellular Screening Against Ubiquitin Ligases HCS, HTS 2016
Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products HTS 2016
Preferential germline usage and VH/VL pairing observed in human antibodies selected by mRNA display Biologics 2015
Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective Microarray 2015
Reduced gene expression levels after chronic exposure to high concentrations of air pollutants Toxicogenomics, NGS 2015
Caspase-8 activation by TRAIL monotherapy predicts responses to IAPi and TRAIL combination treatment in breast cancer cell lines Hit & Lead Identification 2015
Unlocking the Potential of High-Throughput Drug Combination Assays Using Acoustic Dispensing HTS 2015
Combining AZD8931, a novel EGFR/HER2/HER3 signalling inhibitor, with AZD5363 limits AKT inhibitor induced feedback and enhances antitumour efficacy in HER2-amplified breast cancer models Hit & Lead Identification 2015
Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration HTS 2015