Presented at CASSS: Mass Spec, Boston, MA, USA
Allowing unbiased identification and high throughput quantification of multiple low-abundant proteins, mass spectrometry (MS) is proving to be the ideal analytical platform to provide a thorough assessment of host cell proteins (HCPs) in biotherapeutics.
However, the use of MS for HCP analysis also poses some challenges:
We present an instrument- and vendor- independent software platform that allows innovative analytical approaches to address the major
challenges related to the identification, quantification, and routine monitoring of HCPs by MS.