Presented at PEGS, Boston, MA, USA
New strategies and technologies enable a systems biotechnology approach to decipher molecular mechanisms in the cell, and new approaches for the discovery and engineering of genes have significantly improved the ability to produce proteins which resist standard expression methods. For successfully expressing refractory proteins, strategies and methods include specialized engineering of genes/vectors/strains (e.g. focusing on the secretion apparatus), advanced molecular design, integration site determination, CNV and insert integrity analysis and focusing on tightly integrated cell line, media and process development, which may include testing and analyzing multiple combinations.
To address the bioinformatics and data management challenges of this complex research process, we have developed an enterprise software platform, Genedata SelectorTM.
The system supports:
Genedata Selector improves the development of superior expression systems while avoiding the costly loss of knowledge/IP and reducing project time.