End-To-End Software Platform for Streamlined LC/MS-based Multi-Attribute Method (MAM) Implementation

March 11, 2025

We present an integrated software solution that covers the entire MAM workflow, featuring extracted ion chromatogram (XIC) based quality monitoring, automated results review, and an enhanced new peak detection (NPD) component for a scalable end-to-end MAM implementation. We demonstrate that combining an untargeted peptide-mapping-based approach and a targeted XIC-based approach streamlined the accurate identification of new peaks and the efficient monitoring of critical quality attributes while reducing the number of false positives.