Automated Data Analysis and Robust Quality Control for Affinity Selection MS Screening

ASMS, Houston, TX, USA
June 8, 2023

Affinity Selection Mass Spectrometry (ASMS) measures small molecule binders to protein targets. Its capability for multiplexing enables the simultaneous assessment of hundreds of compounds in each well of an assay plate, for a cost-effective high-throughput scanning of chemical space. However, scale and complexity of resulting data
go beyond standard MS analysis and manual quantification. Here we present a new data analysis workflow, implemented in Genedata Screener, which delivers solid hits from large screens by automated compound deconvolution, quantification, quality assurance, tagging - using built-in business logic and an intuitive data review.