A Flexible Infrastructure for Compound Screening and Data Analysis at Academic Screening Centers

ELRIG Drug Discovery, Manchester, UK
September 2, 2014

This poster shows the technological infrastructure and its application to HT-HCS at the Weizmann Wohl Institute for Drug Discovery. First, we illustrate the set-up of an academic small-molecule screening facility maintaining a diverse compound library of 100,000 molecules. The set-up comprises automated workstations and detection technologies for many biochemical and cell-based assays (fluorescence intensity, luminescence, TR-FRET, fluorescence polarization, automated microscopy for high-content screening) at a screening volume of 16,000 compounds per day.

This complex technological backbone also requires a streamlined yet flexible data analysis. We show, secondly, how Genedata Screener^® rationalizes and standardizes the analysis workflow for all assays on a single platform. It unifies quality control and analysis at all stages of a screening campaign, from primary screen to validation and on to comprehensive hit and lead identification across assays using chemical and biological data.

Finally, this state-of-the-art pipeline enables the screening of innovative targets such as a lipid phosphatase, placing the Weizmann Institute at the forefront of Screening.