Case Studies

Description Download Application
HCS Analysis Workflow at Amgen

This application note is a summary of a webinar given by Amgen, describing how Genedata Screener supports the Amgen high content screening (HCS) workflow, including image display, feature selection, and some of the improvements in the new version of Screener.

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Imaging in Drug Discovery - Are We Realizing Its Full Potential?

In this white paper, we review the use of imaging in drug discovery, investigate current and future challenges and outline an infrastructure for image-based workflows to overcome those challenges and allow organizations to realize the full potential of imaging technology.

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Using Additional Metrics in Ion Channel Screening Analysis to Better Understand Underlying Mechanisms

This application note describes how Genedata Screener for Ion Channel Screening was used to introduce an additional informative parameter (the time constant tau) for high-throughput analysis of ion channel modulation from automatic patch clamping (APC) experiments.

A collaboration with Pfizer Neuroscience and Pain Research Unit (Cambridge, UK).

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Reducing Analysis Times for Large-Scale ThermoFluor Assays - A Collaboration With Bayer Pharma AG

This work outlines a universal solution for the analysis of ThermoFluor experiments, using Genedata Screener software. The analysis workflow before this integration consisted of conventional hit selection or an individual review of each melting curve. With the introduction of Screener, the total analysis time was decreased from three days to three hours, and the number of false positives was improved.

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Combination Colloquium Digest: Current Practices and Open Issues in Combination Screening

Compound Combination Screening is rapidly gaining ground as a new lead-finding technique for oncology, infectious diseases, and drug repurposing. At the Genedata SLAS2015 Combination Screening Colloquium, some of the industry's most experienced Combination screening scientists discussed combination screening analysis challenges and methods to meet these challenges. The following short report represents a digest of the colloquium and covers the main discussion topics.

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Automating Analysis of Mass Spectrometry Data to Quantify PTMs with Genedata Expressionist

Data analysis of mass spectrometry data can be automated and standardized to maximize productivity and drive quick, reproducible decisions. Analytical scientists at Janssen R&D’s established a streamlined protocol for the efficient analysis of biotherapeutics.

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High-throughput Metabolomic LC/MS Analysis

An Unbiased Look at the Effects of Oxidative Stress on the Body Using the Thermo Scientific LTQ FT™ and Genedata Expressionist Software.

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Setting Up an HCS Data Analysis System

This case study describes the typical HCS infrastructures and goals, concept, and results for setting up an integrated HCA platform using Genedata Screener® for High Content Screening.

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