Genedata Selector & CRISPR/Cas9 for Precise Genome Editing

Genome editing techniques like the CRISPR/Cas9 system are revolutionizing molecular biology and equipping scientists with the ability to precisely modify the DNA of essentially any organism. Industries from biopharmaceutical to industrial biotech are utilizing the CRISPR/Cas9 method of genome editing for its versatility, ease of use and efficiency. 

While advances in next-generation sequencing technology have made performing genome editing with the CRISPR/Cas9 system faster and easier, researchers still face challenges:

  • Predicting gRNAs for proprietary genomes with publicly available tools and software can be risky to IP
  • Commonly available tools and software programs are not able to incorporate variations in sequence quality within the genome
  • Experimental data determined using CRISPR/Cas9 cannot be incorporated with omics level data for further analysis

Genedata Selector provides one integrated system that allows for the efficient design and management of all relevant CRISPR/Cas9 experimental data.

Key Features of Genedata Selector for CRISPR/Cas9

  • Applicable to all industry and research relevant organisms, both public and proprietary
  • Visualization tools allow for precise genome target selection
  • High quality genome-wide gRNA prediction with lowest possible off-targets
  • Further off-target validation in related organisms like cloning hosts (i.e. E. coli)
  • Sequence level verification of gRNA using locally installed sequence analysis tools 

Genedata has extensive experience in supporting customers using targeted genome editing with the CRISPR/Cas9 system. The integrated platform allows for improved prediction of gRNAs reducing the probability of errors, even with proprietary genomes, thus increasing the success rate of experiments. The centralized and secure storage of gene and genome editing experiments means researchers can quickly share knowledge within their institute and reduce duplication of work.