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NGS Applications

Transform NGS data into innovative applications
for cell line design, metagenomics, and biosafety.

Choose Your Application

Efficient cell line characterization. TLA based clone selection. Precise genome editing using CRISPR. Detection of known and unknown adventitious agents. Metagenome analysis. Genedata Selector® automates innovative workflows.

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Innovative applications for cell line development, process optimization and biosafety

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Industrial Biotech

Novel approaches for metagenome analysis and production strain optimization

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A comprehensive system for comparative genomics in breeding and crop protection

Cell Line Development & Biosafety

Innovative NGS-based applications for cell line development and adventitious agent detection

NGS analysis, pivotal for efficient cell line development, is gaining increasing importance in biosafety with adventitious agent detection in biopharma production. This results in the generation of massive amounts of molecular data and leads to a growing need for data management, automated analysis, and results sharing. 
Genedata Selector is the industry-leading system for enterprise-wide data management and streamlined NGS analysis. It speeds up workflows and creates significant cost savings by bringing standardized data analysis in-house.

Cell Line Development

Host Cell Characterization

In-depth annotation of your proprietary cell line genome sequences is the basis for accurate cell line development and biosafety applications. Genedata Selector integrates public domain data with your proprietary genome sequences (e.g. CHO or HEK cell lines) for functional reconstruction of proprietary genomes, including gene model validation, microRNA analysis, genome structure, mutations, and pathways.

Cross-Omics & Pathway Analysis

The statistical cross-omics data analysis in Genedata Selector allows projection onto pathways to visualize, for example, transcriptome, metabolome and proteome data over different timepoints or experimental conditions. These interactive visualizations enable scientists to identify bottlenecks in the molecular machinery of the cell to determine potential engineering targets.

Gene & Genome Editing

Genome editing techniques such as CRISPR are revolutionizing molecular biology and equipping scientists with the ability to modify the DNA of an organism precisely. Guide RNAs can now be predicted for proprietary genomes in the Genedata Selector secure environment. This removes the reliance on publicly available third-party tools, which can put IP at risk. Experimental CRISPR-based data can also be incorporated with omics-level data for further analysis.

TLA-Based Clone Selection

Cergentis TLA offers a cost-effective, high-resolution technology to determine sequence changes resulting from targeted genome editing, transgene integration sites and breakpoints, copy number variations (CNVs) in the transgene sequence, and structural changes in and surrounding transgene sequences. The push-button analysis pipeline and data management capabilities of Genedata Selector allow our customers to select clones, based on the location of the integration site, and assess the genetic stability of the integration sites.

Cell Line Optimization

Support NGS-based bioprocess development with genotype-phenotype relationship analysis. Guiding cell line optimization, Genedata Selector enables the processing and integration of transcriptomic, metabolomic, and proteomic data to analyze cell line-specific metabolic and signaling pathways. The software allows scientists to perform comparative studies of cell line dynamics, bioprocess formats, and functions depending on experimental design such as varying time points, treatments, or process conditions.


Adventitious Agents Detection

Compared to traditional animal-based biosafety testing, NGS-based biosafety testing saves significant time, produces results in days instead of weeks, and significantly reduces overall costs. In contrast to other targeted detection methods such as PCR, NGS-based adventitious agent detection reduces risk as it also detects novel and unexpected contaminants. With Genedata Selector, the NGS data analysis workflow is now fully automated for in-house analysis.

From Sample Tracking to Reporting

Access to sample information, linked data, analysis performed, and reports generated is crucial for biosafety assessments and regulatory submissions. Genedata Selector simplifies sample management by enabling secure data entry options, graphical data displays for sharing with colleagues, and automated report generation.

Faster Lot Release

NGS-based adventitious agent detection replaces or complements traditional methods. For some traditional assays, it reduces the number of assays and the wait time from more than four weeks to just a few days. In addition to faster cell line banking, lot release for the three days before harvesting samples and final assessment of bio-products that cannot be sterilized, benefit from NGS-based testing.

Product Safety

For product registration with regulatory bodies, proof of a documented audit trail is required. Genedata Selector provides automated sample tracking and report generation using an easy-to-read traffic light presentation of results. In addition, the fully documented software with logged user access and timestamped transaction records allows 21 CFR part 11-compliant operation and integration into a cGMP environment.

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