From primary screening to hit validation and lead development, Genedata Screener lets you scale research using biochemical, biophysical and cellular assays and beyond to several other important and cutting-edge screening modalities. This includes exciting new label-free technologies such as high throughput mass spectrometry.
We are witnessing a trend towards end-to-end automation and data-driven decisions that will make screening in the future faster and easier. Genedata Screener is pioneering that future, with capabilities for real-time analysis, streamlined reporting, and assay annotation via an enterprise-ready assay catalog.
Biochemical and Cellular Assays
Target-based biochemical screens are workhorses of modern high throughput screening. Genedata Screener core functionality readily handles biochemical assays, including those with absorbance, luminescence and fluorescence endpoints. Equally informative are assays that measure signaling in intact cells, and Genedata Screener easily handles FLIPR and reporter-based assays. Whether processing single-point or time-resolved readouts, Genedata Screener helps optimize your plate-based screens.
Automatically calculate and track key QC measures, such as Z’ factor.
Directly import data from a range of industry-standard plate-readers.
Easily view, overlay and fit, and perform automatic calculations on raw signal traces for time-resolved experiments.
High Throughput Mass Spectrometry (HT-MS)
Breakthroughs in sample throughput for mass spectrometry are enabling unprecedented screen sizes. As a label-free method, mass spectrometry promises to shrink assay development times and costs. It delivers rich, high-resolution outputs with readouts of previously difficult-to-detect enzymatic reactions, cellular metabolites, and more. Genedata Screener enables you to:
Easily analyze the latest HT-MS technologies, including Acoustic Ejection Mass Spectrometry (SCIEX’s Echo-MS ®) and pulsed MALDI-TOF (Bruker’s rapifleX PharmaPulse®).
Fully automate spectra analysis including peak detection, quantification, and lookup.
Perform rapid QC with plate-level visualizations and compound-level summaries.
Automated patch clamp enables high-resolution measurement of ion channels—important both as drug targets and for testing in toxicity studies—in their cellular context, at scale. While advances in high throughput electrophysiology instrumentation have led to a dramatic increase in throughput, they have also resulted in new analysis bottlenecks when it comes to analyzing electrophysiological data.
Genedata Screener for Ion Channel Screening addresses these bottlenecks. Supporting the latest electrophysiology instrumentation, Genedata Screener enables you to:
Automate sophisticated normalization, averaging and fitting of time-series data, from patch-clamp experiments across millions of compounds—reducing total data handling and analysis time by upwards of 95%.
Adjust time windows on the fly and have these changes automatically applied to downstream results, for consistent, high-quality analysis.
View electrophysiology traces from within plate-level visualizations and alongside key results, for rapid QC and assessment.
Customers such as Pfizer and Genentech use Genedata Screener to streamline and automate their high throughput patch clamp screens of up to a million compounds.
Have you ever waited until an entire run completed to discover a bad dispenser or a ruined reagent? Now imagine analyzing your data instantly, hot-off-the instrument, and placed in the context of your screen: you can see your results in real-time and intervene right away if errors occur. Conversely, if you’ve already collected more than enough hits, you can stop and move on to the next stage—saving money and time. Do all this and more with Genedata Screener enabling you to:
Open and run an analysis session right as the plates come out of the instrument.
See key assay diagnostics in a central cockpit view and receive email notification in case of experimental emergencies.
Shorten design-analyze-make-test cycles through timely delivery of final results.
Transmitting experimental results to a data warehouse for their dissemination and safekeeping ensures that scientists across an organization can access important information for their projects at a later time. Increasing collaboration with CROs makes this kind of information-sharing even more complex—and even more crucial. Cumbersome procedures involving multiple transfers among software or spreadsheets prevents proper reporting and quickly balloon into a costly waste of time and resources. Using Genedata Screener, you can simplify and standardize reporting. Our consulting team collaborates with you to analyze, streamline, and modernize your reporting workflows to deliver benefits such as:
Direct data reporting from an analysis session in Genedata Screener to data warehouses, with additional one-click export options to PDF or Excel.
Replace procedures involving copy-paste and transposition steps with streamlined, simple workflows.
Multiple options to enable convenient and safe results exchange between CROs and pharma groups, including secure send-and-receive and shared servers among collaborating partners.
Looking at a list of result values is often not enough: to correctly interpret any result, you need to know the biological context and experimental conditions under which such results were collected. This becomes even more crucial when trying to retrieve valuable historical data, which if not properly organized or missing long-forgotten metadata, is rendered useless—a situation you want to avoid. Assay Catalog works together with Genedata Screener to help you:
Label and organize your assays and results using controlled vocabulary and standard protocols, which are easily queried and interpreted for later decision-making.
Reduce information loss and harmonize reporting by ensuring that all experiments are annotated and that all relevant readouts are reported, immediately at source.
Prepare for the future by ensuring that all results stored in data warehouses are appropriately structured, allowing you to take full advantage of potential artificial intelligence methods at enterprise scale.
Screening campaigns consist of multiple stages involving different assays performed on compound libraries and subsets of those libraries. After amassing all this data, how can one most efficiently query, assess, and determine top hits? Copy-pasting your results into a giant master spreadsheet is time-consuming, cumbersome, and error-prone. Moreover, the most current results from ongoing projects must be manually added. With Genedata Screener for Hit Profiling, you can instead:
Rapidly and automatically compile up-to-date screening results across many different assay conditions and assay types in a live spreadsheet.
Complement your screening results with overlay plots and compound properties.
Easily create a report with compound screening results.
Filter compounds to a final list of hits and share it with collaborators.