Jump to content

Biotherapeutic Characterization

Fully leverage your data. Gain deeper insights. Make better decisions.

Peptide Mapping

Identifying and quantifying peptides is key to characterizing and monitoring the quality of biopharmaceuticals. Genedata Expressionist® provides out-of-the-box capabilities for the efficient detection and quantitation of posttranslational modifications (including unexpected wildcard modifications), sequence variants, and glycosylated peptides.

The platform’s open architecture enables you to import data from any search engine or library. Results from different datasets can be combined to give a complete overview across multiple samples. The flexible workflow-based data-processing pipelines enable innovative data-processing strategies that significantly reduce false-positive identifications, typically reducing manual validation efforts from weeks to hours.

Intact and Subunit Mass Analysis

Intact mass analysis enables identification and quantification of entire antibodies and their subunits, and comprehensive characterization of charge variants, antibody-drug conjugates, and protein glycoforms. The refined MaxEnt charge deconvolution algorithm built into Genedata Expressionist dramatically reduces the number of harmonic artefacts.

A unique time-resolved deconvolution algorithm offers unparalleled analysis of coeluting species, literally adding another dimension to insights available to Genedata Expressionist users.

Request the Genmab Case Study

Glycoanalysis

Glycosylation is a critical quality attribute that affects biotherapeutic efficacy and safety. Genedata Expressionist enables rapid and efficient identification of released glycans and characterization of glycosylated peptides and proteins using reference or custom glycan libraries.

An intuitive built-in editor facilitates the addition of complex glycan moieties that are typically absent from generic databases. Using Genedata Expressionist for MS-based glycoanalysis has been shown to deliver time-savings of up to 80% compared to conventional methods.

Request the Merck Case Study

More Applications

Quality Monitoring

Quality Monitoring

Multi-Attribute Method

Multi-Attribute Method

MS-Based Contaminant Detection

Contaminant Detection

MS-Based Bioprocess Monitoring

Bioprocess Monitoring

Genedata Expressionist — All Applications.
Any Instrument. One Platform.

Discover More