Presented at ESACT, May 2017, Lausanne, Switzerland
Sanofi Cell Line Development: Data-driven Approaches for Cell Line Generation and Clone Selection
Michael Hoffmann, Ph.D., Scientist, Cell Line Development Skill Center, Sanofi Genzyme
The development of production cell lines and optimal upstream processes has enormously been accelerated, amongst others, by introducing automation and parallelization such as the usage of scale-down bioreactor models and by applying more and more clone and product analytics methods. This symposium provides insights by experts from the biopharmaceutical industry about their ways of keeping track and analyzing the vast amounts of analytics data and process parameters and how their concepts look like to make data-driven decisions in the area of cell line and upstream process development. The presenters will illustrate their concepts with example case studies and will discuss about future outlooks and challenges on the use of data-driven approaches.