Mass Spec Analytics.
One Enterprise Solution.
All Applications. Any Instrument. One Platform. Genedata Expressionist® streamlines biopharma mass spectrometry workflows across instruments and organizations. It automates and harmonizes all MS data processes to deliver high-quality results with significant time and cost savings.
Our Customers
We especially appreciated the high level of expertise and support provided by Genedata, which enabled us to optimize every stage of our analytical processes—while incorporating industry best practices—and quickly generate high-quality results.
Working with Genedata Expressionist provides us with fast, flexible, and reliable options to discover potential biotherapeutic liabilities and thoroughly analyze next-generation antibodies at Sanofi.
Genedata Expressionist provides high-quality qualitative and quantitative results and its flexible workflow-based approach makes it the ideal platform for processing and analyzing MS data generated using our innovative methods.
Performing preprocessing using Genedata Expressionist delivers a tenfold acceleration in file loading times. High-throughput host-cell protein analysis simply doesn’t work unless you have an efficient automated data processing and annotation workflow.
Oligonucleotide therapeutics bring new challenges, and we needed a trusted partner who could assist us in addressing them. We appreciated that Genedata offered more than just software and that the customized solution — particularly the automation — was exactly what we required.
I really enjoy performing data analysis with Genedata Expressionist, because I know that if the automated workflow needs fine-tuning for a specific therapeutic protein, its flexibility will enable me to easily make the required changes and quickly obtain the results I need.
Automated data processing and report generation provide remarkable time-savings in all our MS-based biopharmaceutical
characterization applications.
We needed something that enabled higher throughputs than the vendor software package we were using, so we turned to Genedata Expressionist. We can give Expressionist hundreds of files, and it is able to process them in a very quick manner.
Genedata developed the end-to-end oligonucleotide QC data workflow and provided the consulting expertise throughout the entire project including the validation stage to help us achieve our goals on time and within budget.
By reducing analysis time from 5–6 hours to less than 30 minutes per sample, Genedata Expressionist enabled us to overcome a major bottleneck in our analytical support of process development.
Using the custom library functionality in Genedata Expressionist streamlined our characterization workflow: reducing analysis times from several weeks to hours, and enabling us to progress quality candidates more rapidly.
Selected Applications
- Characterization
- Quality Monitoring
- MAM Approaches
- MS-based contaminant detection
- MS-based Bioprocess Monitoring
- RNA & Oligonucleotides
Characterization
Enable a better understanding for biotherapeutics by integrating a best-in-class molecular characterization for any MS-based approach like peptide mapping, released glycans, and intact mass analysis.
Combine results from different datasets to give a complete overview across multiple samples, identify and quantify entire antibodies and their subunits. Genedata empowers comprehensive characterization of charge variants, antibody-drug conjugates, and protein glycoforms, as well as the rapid and efficient identification of released glycans and characterization of glycosylated peptides and proteins.
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Quality Monitoring
Leverage insights gained throughout a molecule’s lifecycle and extend beyond overseeing product quality. Genedata enables automated, process-specific system suitability tests (SSTs), which are performed before data is analyzed to ensure instrumentation is performing properly, as well as custom-built reports, that generate and distribute to stakeholders quickly.
The fully automated platform is suited to data processing, analysis, and reporting in QC monitoring of biopharmaceuticals, as well as custom solutions for GxP implementations in regulated environments.
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Multi-Attribute Method Approaches
Combining both in-depth characterization and automated Critical Quality Attribute (CQA) monitoring in a single platform, Genedata provides an end-to-end solution for multi-attribute method (MAM) implementations of a Quality-by-Design framework in biotherapeutic development and production.
The platform offers a centralized knowledge base, which gives product information generated during a drug’s life cycle throughout organizations, allowing full leveraging of content-rich MS data in decision-making.
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MS-based contaminant detection
Genedata enables adapting and evolving MS-based host cell protein (HCP) detection workflows offering a workflow-based solution for the flexible identification and quantification of product and process-related contaminants.
By applying consistency checks to distinguish real signals from noise and building isotope clusters based on known isotopic patterns, the software detects HCPs with high sensitivity (down to low-ppm levels) and high confidence.
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MS-based Bioprocess Monitoring
Looking for a holistic and harmonized solutions for multi-omic approaches to monitoring biotherapeutic production? Genedata supports all biopharma MS applications using any instrument.
It provides automated, standardized processing of complex multi-omics data in a single, scalable system, as well as integrated functionalities for statistical analysis and results display like Principal Component Analysis (PCA) and Partial Least Squares (PLS) representations of multivariate data to uncover relationships between individual- or groups of data sets
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RNA & Oligonucleotides
Genedata provides a flexible platform for streamlining MS data processing, analysis, and reporting throughout the development of RNA-based therapeutics, from early discovery to downstream regulated environments.
Easily exploit the sensitivity and molecular insights provided by mass spectrometry for in-depth characterization and quality monitoring of your RNA and oligonucleotide therapeutics.
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Maximized Productivity for MS in Biopharma
Genedata Expressionist is an open and scalable enterprise software whose unique workflow-based approach enables custom-built solutions that mirror your existing processes, address your specific business and technical needs, and transform your raw data into actionable insights.
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Meet EXPRESSIONIST Customers
Discover how Genedata Expressionist partners are increasing productivity and streamlining their analytical processes.
Learn How We Support Biopharma MS Workflows
Max Productivity. Complete Automation. Total Transparency.
Cutting-edge algorithms and a high-performance server-based infrastructure accelerate processing of data sets of all sizes and complexity, increasing productivity by orders of magnitude.
Automation of repetitive and laborious procedures overcomes data processing bottlenecks while configurable workflows offer complete control of every single processing step. Unique and intuitive visualizations enable data interrogation and facilitate interpretation and understanding of results by linking raw and processed data.
Tailored Solutions. Deeper Insights. Better Decisions.
A thorough assessment of your analytical processes enables our scientific experts to design and implement ready-to-use workflow solutions that address your specific needs. By incorporating consolidated domain knowledge, and out-of-the-box performance, Genedata Expressionist workflows allow rapid transformation of complex MS data into actionable insights.
From discovery to manufacturing, our unique approach provides a solution that leverages industry best-practices and users’ expertise to enable better decision-making.
