Biotherapeutics Discovery.
End-to-End.
Genedata Biologics® streamlines discovery of biotherapeutics including bispecifics, ADCs, TCRs, CAR-Ts, and AAVs. The most widely adopted platform across the industry, it integrates all discovery workflows and automates tasks so you can focus on scientific innovation.
Our Customers
One of the reasons we chose Genedata Biologics was the platform’s process coverage. We required that the full diversity of Pfizer’s large-molecule processes and technologies be supported by one integrated system.
We decided to work with Genedata Biologics because it meets our requirements across all phases of biologics discovery, including novel multi-specific antibody formats and innovative automation methods.
Simon Chell, Ph.D.
Vice President of Biologics Engineering
Genedata Biologics gives all our R&D groups a central place to record and access TCR-related information in real time, along the end-to-end workflow.
We are excited to implement the Genedata Biopharma Platform as a central integrated data backbone to streamline the capture, integration, democratization, and analysis of increasingly complex and diverse data types across Genmab’s discovery and clinical workflows.
We undertook a thorough selection process to find the best antibody workflow platform and Genedata Biologics was the obvious choice.
Genedata Biologics was the clear choice as a backbone system to support the full diversity of our complex and rapidly evolving antibody discovery processes.
We made a decision early on to use Genedata Biologics as MorphoSys’ workflow backbone to accelerate our drug discovery efforts and have watched as Genedata Biologics has become the global industry standard for biopharma discovery organizations.
Genedata seamlessly integrates into an existing research informatics environment and supports the full process through automation, standardization, and integration.
The Genedata platform is the core knowledge management system for our global Biologics Engineering organization, helping us to streamline our research with the aim of developing novel therapies, faster.
Simon Chell, Ph.D.
Vice President of Biologics Engineering
Genedata Biologics is a key component of our growth plans in the immuno-oncology and next-generation ADC space.
Genedata Biologics was the obvious choice because it is a proven, off-the-shelf enterprise platform that can be rapidly deployed across our organization.
A commercial data management solution such as this has been sorely lacking in protein therapeutics.
We appreciate Genedata Biologics’ flexible business model, which made it possible for a company of our size to adopt a market-leading platform solution.
Genedata Biologics will be our central repository for mission-critical data on therapeutic candidates such as bioactivity, developability, and manufacturability, and will enable transparent decision-making on candidates to move forward.
Thanks to Genedata’s flexible business model, we are able to take advantage of Genedata’s unique technology under terms that work well for a company of our size.
Selected Applications
Advancing Bispecific Antibody Discovery
Advance bispecific antibody discovery and automate downstream expression, purification, and characterization processes to substantially increase throughput.
By identifying the most successful combination of antigen binders and formats, Genedata resolves major bottlenecks and enables the systematic design, cloning, and testing of large numbers of bi- and multi-specifics, such as knobs-into-holes (KinH), Fab-scFv, IgG-scFv, DuoBody, DVD-Ig, tandem-scFv-Fc and their parametric variants (e.g., linkers, V-domain order, Fc).
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CARs/TCRs
Streamline cell therapy R&D with purpose-built functionalities for the design and evaluation of large panels of cell-based therapeutic modalities for novel immunotherapies.
By directly integrating with laboratory equipment, Genedata fully automates sample handling and testing procedures. The database and tools support screening and engineering of any format such as chimeric antigen receptors T cells (CAR-T), T Cell Receptor Technology (TCRs), and antibody TCR-mimetics (e.g., dsTCR, TCR-scFv, bispecific TCRs).
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AAVs
Accelerate gene therapy R&D by covering the entire gene therapy workflow, from serotype optimization and viral vector design to virus packaging, purification, and testing.
Genedata tracks all samples and associated information, including customized vectors, packaging plasmids, cell lysates, purified virus batches and their sequences, titers, and assay results such as empty-to-full capsid ratios. Additionally, it supports diverse viral delivery systems including AAV, adenovirus, and retrovirus vectors.
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ADCs
Enable the registration and tracking of large panels of ADC candidates and manage all linker and payload information (e.g., cytotoxic small molecules) by incorporating results from analytics and functional assays in one integrated platform.
Genedata optimizes the full ADC discovery process from antibody screening and engineering to antibody expression, purification, drug conjugation, and reporting of ADC-specific analytics (e.g., DAR, drug distribution, homogeneity).
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Vaccines
Enable novel vaccine discovery by increasing efficiency, facilitating faster testing, simplifying production, ensuring quality, and reducing costs.
Genedata supports novel vaccine technologies such as synthetic self-amplifying mRNA, which accelerates vaccine development by utilizing synthetic and cell-free processes and antigen production, in addition to all classic vaccine R&D.
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RNA Therapeutics
Accelerate end-to-end the design and development of RNA therapeutics and vaccines by leveraging a platform that registers, tests, and evaluates nucleic acid-based therapeutics and vaccines at every stage of development, including RNA/DNA optimization for effectiveness and stability.
Combined with powerful screening workflow tools for formulation development and functional characterization, the platform provides a critical data infrastructure to enable the development of RNA therapeutics faster.
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B-Cells
Facilitate B cell-derived therapeutic antibody R&D by streamlining every stage of the highly complex B cell-based discovery process. Genedata tracks animal and immunization data and registers all molecules, samples, quality control, and functional assay data on a central integrated platform.
ELISA, FACS, and SPR experiments are also managed on the platform. In combination with V-region sequencing results, this allows the unique integration of molecule sequence and functional information.
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Developability
Minimize developability and manufacturability risks by incorporating a systematic assessment of the developability risk profile and critical quality attributes (CQA) of any candidate to decide on the most promising ones to move into development.
The platform assesses a drug’s manufacturability by flagging potential problems such as those during expression and purification and evaluates properties that affect molecule robustness on a biophysical and biochemical level.
Learn MoreExplore the Software
Screening
Designed to enable fully automated, high-throughput screening of biotherapeutic candidates, the software captures, integrates, processes, and interprets selection and screening data derived from diverse discovery technologies, including phage and yeast display, B-cell cloning, and hybridoma.
With built-in sample tracking via integrated plate management functionalities, the platform dramatically increases the efficiency of the early discovery process for antibodies, bi- and multi-specifics, fusion proteins, TCRs, CAR-Ts, and other new modalities.
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Engineering
The software enables efficient engineering of virtually any protein format and the generation of combinatorial libraries from known molecule building blocks. It utilizes built-in tools for designing and optimizing IgGs as well as complex next-generation antibody formats such as bi- and multi-specifics.
The software supports simultaneous improvement of candidate properties such as binding affinity, cross-reactivity, stability, expressibility, and other critical attributes. Advanced tools for affinity maturation, site-directed mutagenesis, germlining, humanization, reformatting, and isotype switching enable rapid and reliable generation of superior protein variants.
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Production
For increased efficiency of the entire protein production process, the software tracks and validates individual steps from the initial definition of the proteins to be produced to the final, fully characterized high-quality samples, including all protein expression and purification batches, as well as vector and cell line batches.
Analytical characterization and QC data such as LC-MS, SEC, HIC, endotoxin levels, glycosylation profiles, and functional data from in vivo assays, are aggregated and directly linked to their respective samples. Certificates of Analysis (CoA) and other relevant sample reports are automatically generated using built-in tools.
Request
The software improves operational efficiency and overall monitoring of R&D operations by supporting the full life cycle of task scheduling. Used to submit and track requests from initiation through completion, it manages intra- and intergroup communications and centrally documents the progression of request fulfillment in real time.
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Meet BIOLOGICS Customers
From large enterprise-wide deployments to single group installations, discover how Genedata Biologics® is used by leading global biopharma, biotechs, CROs, and CRDMOs to increase efficiency and drive innovation.
Learn How We Support Biotherapeutics Discovery
E2E. A Next-Generation Platform.
Acting as a central end-to-end data backbone, Genedata Biologics integrates all R&D processes, from library design and immunizations, selections and panning, molecular biology, screening, protein engineering, expression, purification, and protein analytics, to candidate developability and manufacturability assessments. With its scalable and modular architecture, it fully automates the discovery process and manages the highest data volumes. As a shared platform, it facilitates collaboration among different sites and groups and external partners such as CROs. Real-time access to all relevant data enables users at all levels of an organization to rapidly make more informed decisions, as well as analyze data patterns to drive future discovery programs.
Less Tedious Daily Work.
More Innovation.
Genedata Biologics dramatically simplifies all day-to-day laboratory activities such as cloning, screening, expression, purification, and sample management and automates all data upload, data processing, and reporting. Direct integration with laboratory instruments and robotics stations enables true high-throughput processes. Customers report more than 50% gains in efficiency and improved quality of results.
Optimize Resources. Increase
Productivity. Eliminate Risks.
Providing a central and shared platform, Genedata Biologics gives every R&D team access to all discovery program information for any project at any time. This makes it possible to simultaneously investigate across projects to track program progress and optimize resource usage to improve R&D forecasting, reduce costs, and improve overall productivity.
