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A new analysis capability to improve assessment of cardiac liability in high throughput electrophysiology

Automated patch clamp screens generate highly valuable information for drug research programs. Therefore AstraZeneca has implemented the Nanion SyncroPatch 384PE electrophysiology platform, capturing full kinetics of channel response at higher throughput for hERG and other key cardiac ion channels. AstraZeneca and Genedata then developed a processing and analysis pipeline for this complex data, reading binary raw data directly from the instrument into Genedata Screener, then assigning and integrating the sweep recordings and finally subjecting them to scientists’ review. Additional methods to normalize the cumulative curve recordings and to automatically detect “slow onset” compounds were developed. This investment in a next-generation automated electrophysiology platform and an appropriate automated data processing pipeline is resulting in more predictive and affordable safety screens at high scalability and rapid turnover for discovery projects across AstraZeneca.

June 2017
Ana Teixeira and Matthew Bridgland-Taylor (AstraZeneca, Cambridge, UK)
Request Recording Ion Channel Screening, HTS
Automated Data Processing for Quality Monitoring of Biotherapeutics by Multi-attribute Methods (MAMs)

Joe Shambaugh (Genedata Inc.) presents at 65th ASMS an implementation of MAMs using Genedata Expressionist as single software platform for the data processing, analysis, and management of MS data. In this approach, dedicated workflows are tailored to measure the CQAs for a given biomolecule, while testing for impurities (new peak detection), as well as checking the instrument qualification (system suitability).

June 2017
Joe Shambaugh
Request Recording Mass Spectrometry
Improving the diagnosis and therapeutic outcome of ovarian cancer using novel liquid biopsy tests

Learn about the development of new liquid biopsy tests for early detection and prediction of therapeutic outcome in ovarian cancer.


Breast and ovarian cancers pose huge and still largely unsolved challenges for the medical profession. The EU FP7 EpiFemCare project, to which Genedata was a key contributor, has made significant progress in improving the screening, diagnosis and personalized care of women with such cancers, by developing new liquid biopsy tests based on novel analyses of DNA methylation patterns.

This webinar by Prof. Martin Widschwendter of University College London, coordinator of the EpiFemCare project, gives an overview and discusses the clinical validation and healthcare impact of improved screening and diagnostic tests for ovarian cancer.

Dr. Marisa Fernandez of Genedata discusses how Genedata scientists working with our Genedata Profiler™ platform overcame the challenges of finding tumor specific biomarkers for use as liquid biopsies from highly diluted tumor-specific DNA fragments in blood. We review these challenges, demonstrate the development of new bioinformatics techniques for scanning RRBS methylation patterns unique to tumor samples and discuss the validation of these biomarkers for use as diagnostic and prognostic tests. Finally, we show how combining Genedata's industry leading data science and software can be applied to other precision oncology challenges.

April 2017
Prof. Martin Widschwendter (University College London, coordinator of the EpiFemCare project) & Dr. Marisa Fernandez (Genedata)
Request Recording NGS, Omics, Statistical Analysis
Discovering Therapeutic Combinations for Cancer at UT Southwestern with the help of Genedata Screener

This webinar illustrates how Genedata Screener® for Combination Screening forms an important part of the drug combinations discovery workflow at UT Southwestern Medical Center. Dr. Bruce Posner and Dr. Melissa McCoy demonstrate many of the software features that streamline the processes of data loading, data quality control, dose-response curve analysis, and assessment of the combinatorial effect of user-defined combinations of small molecules at pre-determined doses. As part of the presentation, they show how Screener was used in a project focused on discovering therapeutic combinations for pancreatic cancer (project published in Cell Reports August 2016, Witkiewicz et al.).

December 2016
Melissa McCoy and Bruce Posner, University of Texas Southwestern Medical Center
Request Recording Compound Combinations, Hit & Lead Identification
What's New in Screener 14.0

Genedata released the newest version of our software platform for all in-vitro screening. Download our webinar to learn What's New in Screener 14.0.

Genedata Screener 14.0 meets your data analysis workflow challenges and helps you deliver faster and better. The new version brings improvements within:

Automation and workflows

  • Best-practice workflows assisting expert users and beginners
  • Automated and editable compound mapping
  • Increased efficiency for dose-response curve assay analysis

Result integration

  • Result integration across assays
  • Better overviews with HCS images next to compound results
  • Improved summary views for combination assay results

Collaboration support

  • Simplified and safe sharing of data and results between Screener servers
  • Standardized sharing within the enterprise and with partners with customizable reports
October 2016
Dr. Leigh Foster
Request Recording Hit & Lead Identification
Would You Like to Analyze Multiple APC Plates in One Session?

This webinar demonstrates how Genedata Screener® for Ion Channel Screening is used to analyze automated patch clamp (APC) data. We will show how to analyze and compare plates in parallel, calculate results based on event aggregations, create comprehensive overviews of current traces and of pharmacological parameters that indicate use-dependency, save experiment set-ups for re-use, and report the results. You will see how Screener for Ion Channel Screening:

  • Performs the analysis up to 95% time faster than manual analysis
  • Improves data quality through overviews and comparisons
  • Allows analysis of both small and massive data sets

Download the webinar to learn how you can increase the efficiency of your APC analysis workflow.

June 2016
Jon Tupy
Request Recording Hit & Lead Identification, HTS, Ion Channel Screening
Deconvolution of Intact Mass Spectra: Novel Methods for Deep Characterization of Biotherapeutics

Dr. Mertens presents a novel webcast providing an overview of MS signal deconvolution for intact protein characterization. Working with data collected from a study of monoclonal antibody fragments, he showcases the benefits of innovative time-resolved deconvolution for the in-depth characterization of biotherapeutics.

June 2016
Dominik Mertens
Request Recording Mass Spectrometry
Smarter Crop Improvement through Integrated Genomic Analysis

Genedata Selector is used by leading plant breeders and scientists to manage complex and changing crop genome assemblies and genetic markers; Understand the relationships among diverse data types such as genomes, derivative lines, phenotypes, genotypes, syntenic regions, and metabolic pathways; And access to all available biological data sets while enabling plant scientists to hypotheses, ask complex queries and extract meaningful results.

May 2016
Ben Adamczyk
Request Recording NGS, Strain Development
Webinar: Ensuring patient privacy in multi-omic translational research

Patient clinical trial data represents a huge, often untapped resource for translational research. However its use poses challenges for organizations, principal among which is the need to harmonize and make actionable this complex, distributed data while addressing patient privacy and regulatory concerns.

In this live webinar, Dr. Harri Lempiäinen demonstrates how Genedata Profiler™ is able to overcome these challenges and optimize the process of translational research while ensuring compliance with ever-changing patient privacy regulations.

April 2016
Dr. Harri Lempiainen
Request Recording NGS, Omics, Statistical Analysis
HCS Data Analysis with Genedata Screener

This webinar provides a real-time demonstration of how Genedata Screener® for HCS is used in productive screening by many research organizations around the world. We show how to get a quick overview of assay quality directly after data loading, take a closer look at individual well results and address problematic data points, fit and review dose-response curves, and produce a hit list. We also demonstrate the benefits of viewing images next to the results, and how feature selection and reduction can be done with dendrograms, PCA plots, and LDA.

March 2016
Evan Mulligan
Request Recording Hit & Lead Identification, HCS, HTS
Genedata Selector for RNASeq-Based Gene Discovery and Comprehensive Functional Annotation

Using the barley genome as an example, we demonstrate how Genedata Selector™ can be used for RNAseq-based gene discovery and to enrich novel genes with comprehensive functional annotation. Furthermore we show how to visualize novel annotated genes at the metabolic pathway level and compare the barley genome across different grass species.

March 2016
Sebastien Ribrioux
Request Recording NGS, Omics, Strain Development
Webinar: Leveraging the power of Genedata Profiler for more efficient translational research

Genedata Profiler™ is a new open, interoperable translational research software platform developed in collaboration with leading pharmaceutical companies to effectively process, manage, and analyze omics and phenotypic data to the highest data quality and regulatory compliance standards. 

In this webinar, Dr Lempiäinen demonstrates how the power of Genedata Profiler drives rapid and efficient biomarker identification and validation.

Dr Lempiäinen's demonstration highlights how Genedata Profiler enables the entire translational research workflow from raw data to results and integrates seamlessly with existing in-house platforms (e.g. the open source data warehouse tranSMART).

February 2016
Dr. Harri Lempiainen
Request Recording NGS, Omics, Statistical Analysis
High-Throughput Flow Cytometry Data Analysis with Genedata Screener

This webinar shows concrete examples from a bead-based assay and a 4-Plex Apoptosis assay performed on the IntelliCyt iQue® Screener platform, demonstrating the entire workflow in Genedata Screener for HT-Flow. The live demonstration includes the complete workflow from raw data import, through quality control and dose-response curve fitting, to final results reporting.

December 2015
Matthias Fassler
Request Recording Hit & Lead Identification, HCS
HCS Analysis Workflow at Amgen

Christopher Hale and Dana Nojima present Amgen’s high content screening data analysis workflow using Genedata Screener, from importing raw data from a wide array of HCS instruments to reporting final results.

November 2015
Christopher Hale (Amgen), Dana Nojima (Amgen)
Request Recording HCS, Hit & Lead Identification, HTS
Next Generation Sequencing & Yeast Physiology in Brewing Science

This webinar provides an overview how beverage and brewing companies can enhance process efficiency, product portfolio & quality by using Genedata Selector and next generation sequencing techniques. We show how our comprehensive platform enables a better understanding of yeast physiology and genome wide comparison of production strains for beer, wine and sake.

October 2015
Sebastien Ribrioux
Request Recording NGS, Omics, Strain Development
Webinar: Molecular Characterization of Diseases using Multidimensional Big Data

How to get the most from full interrogation of public and proprietary data to inform decision-making in the development of disease treatment

Dr. Lempiäinen’s presentation covers the entire translational research workflow from raw data to results from the perspective of different user types: Bioinformatician, Analyst, and Biologist.

October 2015
Dr. Harri Lempiäinen
Request Recording NGS, Omics, Statistical Analysis
Genedata Profiler Introduction - Video

This video introduces Genedata Profiler, the number one collaborative enterprise software platform for patient and compound profiling. It empowers scientists to process, manage, and analyze NGS and other omics data from patient samples according to the highest quality and compliance standards, ensuring data privacy and security. Genedata Profiler helps you take control of your data, accelerating your translational research.

July 2015
Request Recording NGS, Omics, Statistical Analysis
Webinar: Unbiased In-Depth Characterization of CEX Fractions from a Stressed Monoclonal Antibody by Mass Spectrometry

In this webinar, Dr. Matthias Berg of Novartis presents his knowledge and first-hand experience using Genedata Expressionist® for Mass Spectrometry for the Unbiased In-Depth Characterization of CEX Fractions from a Stressed Monoclonal Antibody by Mass Spectrometry.

July 2015
Dr. Matthias Berg (Novartis)
Request Recording Mass Spectrometry
Analyzing Corning Epic® and Roche xCELLigence® Data with Genedata Screener®

Biophysical screening is a broad area that encompasses a great variety of technologies. In some cases, the screening is on a smaller scale and answers complex biological questions, other times the questions are simpler and the scale larger. This webinar will focus on how to quickly and efficiently analyze data from two different types of instruments used for biophysical screening, Corning Epic® and Roche xCELLigence®, using Genedata Screener® for Biophysical Screening.

March 2015
Evan Mulligan
Request Recording Hit & Lead Identification, Label-free, Biophysics
Webinar: LC-MS Peptide Map Profiling – From Raw Data to Batch Reporting

In this live webinar, we describe a workflow for the data analysis of LC-MS peptide map experiments going from raw data to a standardized and yet flexible batch reporting.

October 2014
Dr. Carsten Sönksen (Novo Nordisk), Dr. Arnd Brandenburg (Genedata)
Request Recording Mass Spectrometry