Genedata Releases Screener Version 3.0

A Dedicated Screening Analysis Environment with Unique Tools for Cross-Assay Bioactivity Profiling and Structural Clustering

Basel, Switzerland, September 2, 2004

Genedata announced today the release of version 3.0 of Screener®, a fully integrated data
analysis and management system for high throughput screening and compound profiling. Combining information from screening data, pharmacological properties, and chemical structure, the new version of Screener serves to pinpoint false-negatives, reduce false-positive rates and provide valuable guidance for lead optimization. Analysis workflows are streamlined considerably and interpretation of results is automated by means of screening specific algorithms.

"The new functionalities and improvements to Screener result from close collaboration with our development partners; leading companies in the field of drug discovery," says Dr. Stephan Heyse, project leader for Screener. "The computational system enables in-depth characterization of compounds and structural clusters at an early stage of the drug discovery process, serving to increase success rates and reduce the costs of pharmaceutical research."

Screener's new Sarileo module integrates state-of-the art chemoinformatics functionality such as similarity search, compound clustering and chemical homogeneity profiling into Genedata's high-performance platform for cross-assay bioactivity profiling. The new chemical cross validation module exploits advanced classification algorithms to validate structure-activity hypotheses. For the first time, scientists can routinely and systematically relate screening data to compound and assay information via integrated databases.

Reliability of results and availability of data are critical for arriving at meaningful conclusions. Screener facilitates these by automating processing and structuring data and related information. Screener’s well-structured approach significantly accelerates data processing, while at the same time increasing data quality by performing automated quality filtering using validated algorithms. Its powerful, yet lightweight operational database connects specialized workflow modules within an integrated system. Built-in reporting functionalities support company-wide result sharing. Sophisticated audit trail functionalities provide full QC throughout the screening workflow. With its flexible and easy-to-implement interfaces Screener fits into any corporate IT environment.

About Genedata
Genedata transforms life science data into intelligence with a portfolio of advanced software solutions and scientific consulting. With award-winning platforms, combined with deep domain expertise, Genedata enables dramatic increases in productivity and quality of research, development, and production. Founded in 1997, Genedata is headquartered in Switzerland and has offices in Germany, the UK, Japan, and the  US.

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