The Genedata Vaccine Solution

Vaccines represent one of the most crucial public health advances in human history. However, the discovery, development, and manufacturing of prophylactic and therapeutic vaccines to protect people against infectious and other diseases remains very challenging.

The Genedata Platform has been designed to increase the efficiency and quality of vaccine research, development, and manufacturing. The end-to-end enterprise platform supports the full discovery and development process for novel vaccines and enables faster and better testing, simplified production, and reduced costs. It supports not only classical vaccine R&D approaches, but also novel vaccine technologies such as synthetic self-amplifying mRNA and other innovative vaccine R&D techniques, accelerating the development of novel vaccines.

  

Enabling Next-generation Vaccine R&D through Digitalization

The Genedata Platform is a dedicated, purpose-built enterprise software system that accelerates vaccine discovery and development, automates complex R&D processes, supports teamwork in a division of labor environment, and integrates new R&D technologies and workflows. In particular, it supports:

  • Novel protein- and peptide-based subunit vaccine design

  • Innovative DNA and RNA vaccine engineering (e.g., self-amplifying messenger RNA)

  • Novel adjuvants discovery (e.g., via HT screening of immuno-potentiators)

  • Vaccine bioprocess development, including USP and DSP, formulation

  • High-throughput R&D processes (e.g., systematic use of scale-down bioreactors)

  • Automation and robotics integration (e.g., high-throughput formulation screening)

  • Novel technologies (e.g., polysaccharide vaccines, GMMA)

  • Presentation and delivery (e.g., alpha-virus vectors, vaccinia or baculovirus vectors)

  • Innate immune trigger identification

  • Biosafety assessment (e.g., NGS-based screens for adventitious agents)

  • Support of synthetic and cell-free processes

  • Reverse vaccinology based on whole-genome analysis of the pathogen

  • Bioconjugates management and testing

  • Cancer vaccine discovery

 


Vaccine Discovery

Increase efficiency of vaccine research

  • Manage the entire E2E workflow, from molecular biology to screening and production
  • Produce and characterize recombinant nucleic acids, peptides, proteins and viruses
  • Investigate novel antigens and identify relevant epitopes
  • Streamline gene synthesis workflows for antigens and immunogens

Establish high-throughput discovery processes

  • Automate and scale up cloning, screening, engineering, expression, and purification  
  • Integrate all lab instruments to automate data transfer, e.g., for screening and analytics
  • Generate vectors in large-scale through bulk in silico cloning 
  • Ensure continuous process monitoring

Take an integrative systems biology approach

  • Enable a holistic analysis of all data across projects and programs
  • Facilitate communication between different teams and functions 
  • Optimize processes by systematically identifying R&D process bottlenecks
  • Integrate new technologies via open architecture

 

 

Vaccine Development

Optimize vaccine bioprocess development

  • Optimize yields and purities in expression and purification processes
  • Integrate cell line selection, USP, DSP, formulation, and analytics workflows
  • Streamline communication and handovers between different teams
  • Automate all processes by directly integrating bioreactors or analytics devices

Monitor vaccine product quality and integrity

  • Integrate all characterization and analytics data (e.g., antigens, protein sub-units, viruses, nucleic acids)  
  • Identify potential developability risks based on integrated product quality assessment
  • Correlate manufacturing process parameters with product quality; full QbD support
  • Generate full historical record for each vaccine candidate in a single mouse click

Ensure data integrity & compliance

  • Enable full traceability from raw materials to final product using comprehensive sample barcoding
  • Establish a single-source-of-truth by providing real-time access to all project information 
  • Rely on an established enterprise platform based on industry standard architecture
  • Enforce data integrity and compliance due to centralized data management


To find out how Genedata can help increase the efficiency and quality of your vaccine research, development, and manufacturing, email vaccines@genedata.com.