Dealing with the Combinatorial Complexity of Protein Engineering: Bi- and Multi-Specifics, TCRs, and CAR Ts

Presented at PEGS Boston, Virtual Meeting
Amanda Fitzgerald, Ph.D., Senior Scientific Consultant, Genedata

We present a new technology platform to fully automate both molecular design, as well as the integrated assessment of potency, efficacy, and developability profiling of large panels of bispecific candidates. We will present use cases showing how the platform allows for the systematic cloning, expression, purification, and characterization of complex multi-specific, CAR T and TCR modalities, with a focus on immuno-oncology applications.