Time-resolved Deconvolution for Automated, In-depth Characterization of an IgG-type Monoclonal Antibody by Intact Mass Analysis

June 5, 2019

Presented at ASMS 2019, Atlanta, GA, USA

Heterogeneity, aggregation, and physical and chemical degradation can adversely affect efficacy of biotherapeutics and cause safety issues. Selecting the best possible drug candidate requires extensive molecular characterization to mitigate the risk of failing in late stages of drug development. Here we present an innovative and unique deconvolution method to leverage intact mass analysis for automated screening and in-depth characterization of antibodies.

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