An Integrated Knowledge Management & Data Analysis Platform for Cell Line Development & Cell Culture R&D

June 4, 2015

Presented at ESACT, Barcelona, Spain

New technologies have changed the way in which cell line engineering and cell culture R&D generally is performed. However, genomic and molecular data are often scattered in different locations and not easily accessible. Additionally, data quality issues may be inadequately tracked, leading to suboptimal decisions and increasing the risk of project failure. Complex workflows may require different tools or may not be supported by available solutions.
To address these challenges, we developed a single, integrated knowledge management and analysis platform, Genedata Selector™. The system integrates varied public and proprietary “omics” data from different sources and is highly scalable, being able to handle hundreds of genomes and related information. Additionally, all publicly available CHO cell lines and the Chinese hamster genome with refined gene models, improved functional annotation, TFBS and pathway information are integrated in this one platform. The system provides a comprehensive knowledge base with reference data to support:

  • Determination of insertion sites and integrity of expression vectors
  • Definition of genetic engineering strategies
  • Gene and genome editing (CRISPR sites in any genome)
  • Annotation of proprietary genomes and refinement of gene models
  • Integration of omics data to understand differences between cell lines, growth media or time points
  • Rationalization of cell culture process and media development

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