ウェビナー動画：MSD社、バイオ医薬品に含まれる界面活性剤のMSを用いた効率的な同定化

本動画では、Merck Sharp & Dohme (MSD) 社 Senior Scientist の Rong-Sheng Yang 氏が登壇し、Genedata ExpressionistのカスタムMSピークライブラリと直感的な可視化機能を活用することで、バイオ医薬品に含まれる界面活性剤を効率的に同定化している方法を紹介しています。

Polymeric excipients such as polysorbate 20/80 and poloxamer 188, which are used in formulation of biotherapeutics, share the polyethylene oxide building block. Charge-reduction mass spectrometry (MS) coupled with two-dimensional ion density mapping has been used for rapid profiling, fingerprinting, and speciation of such polymeric excipients. 

This approach has proven to be a fast and effective tool for the visualization of intact polymeric species but has inherent challenges due to the heterogeneity of the polymeric species and the complexity of the resulting MS data. 

Discover how Genedata Expressionist empowers scientists at MSD with:

• A tailored data processing solution utilizing custom MS peak libraries.
• Intuitive visualizations enabling fast, in-depth characterization of polysorbates.
• An accelerated workflow for the identification of polymer excipients in biotherapeutic drug products.