ポスター：ハイスループットスペクトルシフト（HT-SpS）解析ワークフローの自動化

October 1, 2025

Genedata Screener^®によるワークフロー全体のオートメーションは、HT-SpSを用いたヒット検出に比類のない拡張性をもたらします。NanoTemper Dianthus uHTS 装置のデータ取得・処理、品質管理、ヒット同定、レポーティングを自動化することで、創薬初期段階における新規分子の同定を加速します。

High Throughput Spectral Shift (HT-SpS) is a cutting-edge biophysical screening technology that enables direct detection of binders and allosteric modulators, including both small molecules and biologics. For the first time, hits can be identified through direct biophysical measurements at the earliest stages of drug discovery. The NanoTemper Dianthus uHTS is a high-performance instrument based on SpS technology, capable of measuring a full 1536-plate in approximately 7 minutes.

Here we present an automated end-to-end workflow in Genedata Screener^®, part of the Genedata Biopharma Platform, that enables HT-SpS hit detection with unprecedented throughput. Genedata Screener fully automates the entire analysis workflow for Dianthus uHTS data, including data loading, processing, quality control, result calculation, hit identification, and reporting to downstream applications. It efficiently handles diverse (HT-)SpS datasets, enables interactive review of raw spectral scan graphs at any step, performs automated outlier detection, provides robust QC metrics, and supports sample ranking via direct affinity constant determination.  With the addition of SpS to the broad suite of assay technologies covered, Genedata Screener thus continues to accelerate the identification of new molecules from the beginning of the discovery cycle.