Enhancing Analysis Efficiency in High-Throughput Semi-Targeted Intact Mass Spectrometry

June 2, 2025

To identify the most effective compound during drug discovery, it is essential to study how drug candidates interact with target proteins at a molecular level and characterize any structural modifications. Intact covalent binding mass spectrometry detects both unbound targets and compound-bound complexes, providing crucial insights. While untargeted workflows identify and characterize all sample elements, they are time-consuming and require extensive manual review. The integrated workflow of the Genedata Biopharma Platform combines rule-based automated analysis with manual assessment, improving efficiency and accuracy.