Upstream process development (USP) is a critical step in bioprocess development. The systematic testing and assessment of different process parameters and their combinations can have a profound effect on product titers and quality. New bioreactors, in particular scale-down systems such as ambr®, and process analytical technologies (PAT), have led to more readout data (online, offline and at-line), that need to be captured, processed, and analyzed in the context of applied process parameters.
Genedata Bioprocess® makes the development of new or optimized fed-batch and perfusion upstream processes more efficient by supporting all workflows, starting with cell banking via serial sub-cultivation for both seed train expansion and clone stability assessment, to shake flask and bioreactor production runs of any scale. The platform helps to significantly reduce timelines and costs when generating robust and high-yield upstream processes to be upscaled for large-scale production of protein therapeutics.