Automated Data Analysis That Matches Mass Spectrometry Throughput
The biopharmaceutical industry’s best-in-class data analysis platform Genedata Screener® has now been extended to high-throughput mass spectrometry screening applications.
The new functionality Genedata Screener for Mass Spectrometry (MS) Screening offers ready-to-go workflow templates for the typical assay formats:
- Affinity selection mass spectrometry assays (ASMS)
- Multiple reaction monitoring assays (MRM)
- A range of covalent binding assays
Genedata Screener for MS Screening allows scientists to:
- Efficiently and comprehensively analyze MS screens.
- Automate MS data analysis to maximize the throughput of routine analysis.
- Easily identify molecule of interest due to peak and cluster annotations.
Overcoming Bottlenecks with High Throughput Analysis
Mass spectrometry instruments have reached a sample throughput that positions MS as a high-quality, cost-effective, and fast alternative to a range of standard assay technologies. However, the magnitude of data they produce requires an analysis solution up to the task. Devised from its origin to support high-throughput experimental set-ups, Genedata Screener® captures and processes mass spectra from screening assays to reliable, high-quality results at ever-increasing acquisition speeds and throughput.
Templated Raw Spectra Processing Workflows, Out-of-the-Box
Genedata Screener for MS Screening simplifies data analysis and quality assurance from MS-based binding and activity assays. It comes ready to support Affinity Selection Mass Spectrometry (ASMS), Multiple Reaction Monitoring (MRM), and a variety of Covalent Binding screens. Simply select the quantification method, and raw data, and let Screener do the rest, directly yielding end results for the assay.
Automated Analysis, End-to-End
Genedata Screener imports raw data from all major MS instruments and combines them with metadata from compound registration and other systems to automatically parameterize MS analysis to each sample in the screen, e.g. adjusting the peak window by the molecular weight per sample. Genedata Screener fully automates spectra processing—including deconvolution, peak detection, quantification, and look-up— as well as downstream data analysis, quality control, and reporting.
Comprehensive Evaluation of MS Screens
Genedata Screener comes with years of screening knowledge built-in. Genedata Screener makes them available to MS screening scientists, in the form of built-in screening concepts such as plate and assay quality metrics, replicate condensing, concentration-response curve fitting, compound annotations, business rules, and reporting. The large data volumes typically produced in screening campaigns require comprehensive data overviews. Genedata Screener offers data visualizations at different levels— assays, plates, wells, spectra, and compounds—for data interpretation at a glance. Genedata Screener thus enables the integration of MS-based assays with industry-standard screening quality control and analysis practices.
Solution Of Choice
Data analysis in Genedata Screener matches instrument throughput, removing the analysis bottleneck and thus increasing ROI of mass spectrometers. Further, it enables scaling up of assays, increasing the productivity of your assay and screening laboratories. The world’s top pharma, biotech, and contract research organizations rely on Genedata Screener for streamlining assay data analysis and management and to expand the use of innovative assay technologies across research and development