Scientific Publications

The peer-reviewed publications listed below each acknowledge support from Genedata.

     
Title Authors Source Application Year
Integrated transcriptomic and proteomic evaluation of gentamicin nephrotoxicity in rats

Com E, Boitier E, Marchandeau JP, Brandenburg A, Schroeder S, Hoffmann D, Mally A, Gautier JC

 Toxicology and Applied Pharmacology Statistical Analysis, Microarray 2012
Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity

Yildirimman R, Brolén G, Vilardell M, Eriksson G, Synnergren J, Gmuender H, Kamburov A, Ingelman-Sundberg M, Castell J, Lahoz A, Kleinjans J, van Delft J, Björquist P, Herwig R

 Toxicological Sciences Statistical Analysis, Microarray 2011
A comparative integrated transcript analysis and functional characterization of differential mechanisms for induction of liver hypertrophy in the rat

Boitier E, Amberg A, Barbié V, Blichenberg A, Brandenburg A, Gmuender H, Gruhler A, McCarthy D, Meyer K, Riefke B, Raschke M, Schoonen W, Sieber M, Suter L, Thomas CE, Sajot N

 Toxicology and Applied Pharmacology Microarray, Mass Spectrometry, Statistical Analysis, Toxicogenomics 2011
EU Framework 6 Project: Predictive Toxicology (PredTox)—overview and outcome

Suter L, Schroeder S, Meyer K, Gautier JC, Amberg A, Wendt M, Gmuender H, Mally A, Boitier E, Ellinger-Ziegelbauer H, Matheis K, Pfannkuch F

 Toxicology and Applied Pharmacology Toxicogenomics, Statistical Analysis, Microarray, Mass Spectrometry 2011
The enhanced value of combining conventional and “omics” analyses in early assessment of drug-induced hepatobiliary injury

Ellinger-Ziegelbauer H, Adler M, Amberg A, Brandenburg A, Callanan JJ, Connor S, Fountoulakis M, Gmuender H, Gruhler A, Hewitt P, Hodson M, Matheis KA, McCarthy D, Raschke M, Riefke B, Schmitt CS, Sieber M, Sposny A, Suter L, Sweatman B, Mally A

 Toxicology and Applied Pharmacology Microarray, Mass Spectrometry, Omics, Toxicogenomics 2011
Deglycosylation and label-free quantitative LC-MALDI MS applied to efficient serum biomarker discovery of lung cancer

Toyama A, Nakagawa H, Matsuda K, Ishikawa N, Kohno N, Daigo Y, Sato T, Nakamura Y, Ueda K

 Proteome Science Mass Spectrometry 2011
A comprehensive peptidome profiling technology for the identification of early detection biomarkers for lung adenocarcinoma

Ueda K, Saichi N, Takami S, Kang D, Toyama A, Daigo Y, Ishikawa N, Kohno N, Tamura K, Shuin T, Nakayama M, Sato T, Nakamura Y, Nakagawa H

 PLoS ONE Mass Spectrometry 2011
Cross-study and cross-omics comparisons of three nephrotoxic compounds reveal mechanistic insights and new candidate biomarkers

Matheis KA, Com E, Gautier JC, Guerreiro N, Brandenburg A, Gmuender H, Sposny A, Hewitt P, Amberg A, Boernsen O, Riefke B, Hoffmann D, Mally A, Kalkuhl A, Suter L, Dieterle F, Staedtler F

 Toxicology and Applied Pharmacology Microarray, Mass Spectrometry, Statistical Analysis, Toxicogenomics 2011
In vitro cytokine release from human peripheral blood mononuclear cells in the assessment of the immunotoxic potential of chemicals

Stølevik SB, Nygaard UC, Namork E, Granum B, Pellerud A, van Leeuwen DM, Gmuender H, van Delft JH, van Loveren H, Løvik M

 Toxicology In Vitro Omics, Toxicogenomics 2011
H5N1 virus ativates signaling pathways in human endothelial cells resulting in a specific imbalanced inflammatory response

Viemann D, Schmolke M, Lueken A, Boergeling Y, Friesenhagen J, Wittkowski H, Ludwig S, Roth J

 J. Immunol. Microarray 2011
Proteomic analysis of native hepatocyte nuclear factor-4a (HNF4a) isoforms, phosphorylation status, and interactive cofactors

Daigo K, Kawamura T, Ohta Y, Ohashi R, Katayose S, Tanaka T, Aburatani H, Naito M, Kodama T, Ihara S, Hamakubo T

 J. Biol. Chem. Mass Spectrometry 2011
HMGA proteins regulate the expression of FGF2 in uterine fibroids

Helmke BM, Markowski DN, Müller MH, Sommer A, Müller J, Möller C, Bullerdiek J

 MHR Microarray 2011
Differential endothelial cell gene expression by African Americans versus Caucasian Americans: a possible contribution to health disparity in vascular disease and cancer

Wei P, Milbauer LC, Enenstein J, Nguyen J, Pan W, Hebbel RP

 BMC Medicine Microarray 2011
CXCL12 Mediates Immunosuppression in the Lymphoma Microenvironment after Allogeneic Transplantation of Hematopoietic Cells

Dürr C, Pfeifer D, Claus R, Schmitt-Graeff A, Gerlach UV, Graeser R, Krüger S, Gerbitz A, RNegrin RS, JFinke J, Zeiser R

 Cancer Research Microarray 2010
Transcriptomic profile indicative of immunotoxic exposure: in vitro studies in peripheral blood mononuclear cells

Hochstenbach K, van Leeuwen DM, Gmuender H, Stølevik SB, Nygaard UC, Løvik M, Granum B, Namork E, van Delft JH, van Loveren H

 Toxicological Sciences Omics, Microarray, Statistical Analysis, Toxicogenomics 2010
Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication

Karlas A, Machuy N, Shin Y, Pleissner KP, Artarini A, Heuer D, Becker D, Khalil H, Ogilvie LA, Hess S, Mäurer AP, Müller E, Wolff T, Rudel T and Meyer TF

Nature HTS 2010
Identification and Characterization of Novel Small Molecules as Potent Inhibitors of the Plasmodial Calcium-Dependent Protein Kinase 1

Lemercier G, Fernandez-Montalvan A, Shaw JP, Kugelstadt D, Bomke J, Domostoj M, Schwarz MK, Scheer A, Kappes B, Leroy D

Biochemistry HTS 2009
Quantitative Assessment of Hit Detection and Confirmation in Single and Duplicate High-Throughput Screenings

Wu Z, Liu D, Sui Y

 J. Biomol. Screen. HTS 2008
Robust Hit Identification by Quality Assurance and Multivariate Data Analysis of a High-Content, Cell-Based Assay.

Dürr O, Duval F, Nichols A, Lang P, Brodte A, Heyse S, Besson D

 J. Biomol. Screen. HTS, HCS, Statistical Analysis 2007
Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease

Zheng W, Padia J, Urban DJ, Jadhav A, Goker-Alpan O, Simeonov A, Goldin E, Auld D, LaMarca ME, Inglese J, Austin CP, Sidransky E

 PNAS HTS 2007