Highlights

See Assay Analyzer, Condoseo and Hit Profiler in action, or how to accelerate the analysis of your label-free experiments in our recent webinars.

 

Modules and Extensions

Genedata Screener® consists of seven modules and extensions, an application server, and database. These components work together as a single system to process, manage, and analyze data from plate-based screening. Producing high-quality results for all screening operations, Genedata Screener modules feature sophisticated algorithms and visualization tools for scalable data management and advanced data analyses. Specific support for data from High Content, Cell Population, Time-Series, or Compound Combination experiments is provided through Genedata Screener extensions. Built-in decision support tools, global reporting, and publication functions support day-to-day quality control and result-generation and sharing.

Assay Analyzer
Quality control, hit picking and gene ranking

Assay Analyzer imports and automatically processes data from all screening instruments following pre-defined protocols. Advanced algorithms correct process-induced inhomogeneous data and automatically mask poor measurements. You can review results and interactively refine processing and masking. Advanced filters enable easy yet fully documented quality control. Specific support for replicate analysis incl. multi-level condensing for siRNA processing and Gene ranking. Assay Analyzer loads and processes a typical HTS run (100x 384 well plates) within seconds.

Condoseo
Automated Dose-Response Curve fitting

Condoseo software, dose-response curve data analysis

Condoseo fits 10,000 Dose-Response Curves (DRC) in seconds, allowing you to rapidly and consistently optimize the fits for large compound sets. Built-in algorithms for automated outlier masking and heuristics for model selection ensure high-quality results. Graphical overviews show global potency distribution and indicate quality issues, enabling immediate action. All centrally-stored results can be exported as reports.

Hit Profiler
Compound profiling

Hit Profiler automatically imports thousands of biological results for compounds, including activities or potencies, from any data source and displays them in a compound-centric table, side-by-side with DRCs and chemical structures. Combined with Genedata Screener Extensions, Hit Profiler also displays HCS images and Time-Series traces.  Scatter plot and fast filters support efficient identification of interesting compound sets. A flexible annotation framework captures the user’s interpretation results. You can rapidly profile large compound sets to find hits and leads of interest and to select compound series for further progression.

Compound Synergy Extension
Compound combination experiment analyses

Genedata Screener Compound Synergy Extension supports analysis of compound combination experiments. Such experiments are characterized by the systematic combination of two compounds in different concentration (cross dilution) and a multiple-step data analysis procedure. Genedata Screener provides an easy and efficient way to analyze these experiments in a single software environment and review results including key visual displays such as the excess matrix.

High Content Extension
High content image integration and analyses

Genedata Screener High Content Extension supports massive, multi-featured data, typical for High Content Screening. It integrates with data and image storage systems and provides instant access to images without further user interaction (navigation). Its powerful statistics and navigation capabilities find and inspect features of relevance, cross-feature filters create meaningful HCS hit lists, or Gene rankings. Together with the High Content Extension, Screener enables processing of HCS experiments as part of the screening data analysis pipeline.

Cell Population Extension
Cell population analysis

Genedata Screener Cell Population Extension supports interactive processing of single-cell data from High Throughput Flow-Cytometry, High Content Screening and related technologies. In a single view, you can define, manage, and display cell sub-populations of a complete assay data set and use cell sub-populations as input for cell-to-well data aggregation. 

Time-Series Extension
Time-series and label-free analyses

The Genedata Screener Time-Series Extension supports data capture and analysis for time-series experiments from experimental technologies such as automated patch clamping, label-free assays, thermal shift assays, or time-resolved fluorescence. Central management of time-series data versus distributed storage on individual instruments fosters standardized business rules and quality criteria for curve analysis independent of instrument or technology.