The steadily increasing number of hits generated in HTS has created a bottleneck: the diligent assessment of a hit`s potential and subsequently the decision on compound progression. Depending on a delicate balance of initial potency, side effects, mechanistic considerations, ADME/Tox properties and freedom of operation, to just name a few, the Hit-to-Lead process is a truly multidimensional exercise. Looking at the multi-dimensional nature of the task, the simultaneous consideration of multiple criteria would be essential. However, structural clusters for downstream in-vivo experiments and lead optimization are still filtered sequentially, as accessing, compiling and sharing the information on compounds proves to be difficult.
Screener`s Hit Profiler module eliminates the bottleneck. It provides access to a wide variety of data and enables their filtering, annotation, interpretation and communication across interdisciplinary teams.

Benefits of Screener`s application in the Hit-to-Lead process

• Rapid data retrieval, interactive visualization, rule based filtering, and structured annotation of large compound sets
• Efficient compound and cluster selection by multiple criteria over the entire hit-to-lead process
• Data compilation across corporate sources via open, easily implemented APIs
• Effective communication within lead finding teams and across the corporation

Read more about Screener.