PEGS Protein Engineering Summit

April 29 - May 3, 2013

Boston, MA, USA

Meet Genedata experts at PEGS Protein Engineering Summit to learn how to streamline biologics discovery and development processes - from antibody screening, protein engineering and production to biotherapeutic characterization.

To schedule a meeting in advance, please contact Genedata at

Recommended Presentations

Automated High-throughput Antibody Discovery and Optimization
Christopher Smith, Ph.D., Scientific Consultant, Genedata Inc.

Phage and Yeast Display of Antibodies and Recombinant Proteins Session
Monday, April 29, 2013, 12:10 - 12:40 pm

Together with leading biopharmaceutical companies, we have developed Genedata Biologics, a workflow system that streamlines laborious, manual laboratory processes in antibody screening, protein engineering and production. We present concrete screening automation use cases from working with phage, yeast, mRNA display, and hybridomas and B-cells. We also present our novel high-throughput in silico cloning tools for systematic generation of next-generation antibody molecules, including bispecifics, and their subsequent automated expression, purification, and characterization.

Fast and Reliable Identification of Differences in Large Peptide Mapping Data Sets of Stressed Recombinant Proteins
Matthias Berg, Ph.D.,Technical Lead, Mass Spectrometry, TRD, Biologics Process R&D, Novartis

Next-Gen Characterization Methods for Biotherapeutics Session
Tuesday, April 30, 2013, 12:15 - 12:45 pm

Therapeutic antibodies are exposed to different stress conditions during their characterization phase in order to find and identify possible sites of modifications and their impact on the bioactivity. Antibody samples are exposed to oxidative, light, shaking, or temperature stress conditions. The treated samples are digested with a protease and resulting peptides fragments are analysed by LC-MS/MS. The challenge is to evaluate these large data sets in a suitable time frame, identify and quantify reproducibly any modifications due to the stress conditions.