Integrated Strain Development Platform

Genedata's Integrated Strain Development Platform (ISDP) is a comprehensive data management and analysis system for industrial biotechnology. The ISDP supports various strain optimization strategies for industrial microorganisms used in fermentation and other biotech processes for the production of enzymes, feed and food supplements, fine chemicals and biofuels.

The ISDP includes an integrated set of tools to support rational strain development programs, including identification and prioritization of novel metabolic engineering targets, cloning and genetic engineering. The ISDP provides tailored modules for processing, storing and analyzing next-generation sequencing data from strain re-sequencing projects. These functionalities are pivotal in investigating re-sequenced, mutagenized strains from screening efforts and identifying novel production-enhancing alleles. The ISDP automatically identifies mutations, and evaluates their impact at different biological levels – from the single nucleotide level to the whole-genome pathway level.

Built on an Oracle™ database, the ISDP enables integrated storage of all relevant information on the strain’s genotype, production performance and ancestry, together with relevant molecular and functional annotations. Powerful query and graphical analysis tools allow rapid filtering of targets and mutations and their prioritization for follow-up laboratory experiments. The ISDP provides comprehensive functionalities for working with one or few reference strains, to large-scale cross-strain comparisons. With robust scalability, the ISDP enables an integrated analysis of thousands of strains at the same time.

The platform caters to any type of prokaryotic or eukaryotic cell system, and can be accessed by laboratories and business units in multiple locations working with different production organisms. The typical target users of the ISDP are scientists and technical personnel involved in strain development including molecular biology, screening, fermentation, up-scaling and process development.

The ISDP provides a central resource around which strain development operations in a division-of-labor environment can be coordinated. IP protection is facilitated through consistent documentation and reliable and easy access to production-relevant genotypic and phenotypic information.

Please check back for the latest developments in strain development at Genedata or contact us to receive more information.